4.83 Based On 50,000+ Satisfied Customers

Ultimate Methylene Blue 1% 30mL (1.0 oz)

Ultimate Methylene Blue 1% 30mL (1.0 oz)

Feel clear, focused, and energized

Wake up with real & lasting energy

Think clearer & stay focused all day

Remember more & support long-term brain performance

Support deep recovery & cellular repair from fatigue

$32.99
$32.99
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

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Ultimate Methylene Blue 1% 30mL (1.0 oz)

Ultimate Methylene Blue 1% 30mL (1.0 oz)

$32.99
$32.99
SAVE Liquid error (snippets/price line 116): Computation results in '-Infinity'% Sold out

Our team is available around the clock to answer any questions about your product.

If you’re not fully satisfied, we offer a hassle-free 100% money-back guarantee within the first 30 days.

  •  

    Allen | VERIFIED PURCHASE

    "My mental clarity is much greater, brain fog is leaving, and my overall energy level vastly improved within the first two days of using this stuff"

  •  

    Bill Brewer | VERIFIED PURCHASE

    This is true, I did 6 drops today and at work I was so focused and got everything done. The energy I had was awesome. Thank you TryAnnie.

  •  

    Bobbi | VERIFIED PURCHASE

    My husband takes this. His memory has improved, he no longer has sleep apnea and has more energy, does things now rather than being a couch potato.

  •  

    Clare | VERIFIED PURCHASE

    I love this stuff! It helps with ADHD and chronic fatigue (for me anyway). I use about 2 full droppers in a 4L jug of water.

  •  

    Jamie | VERIFIED PURCHASE

    Been on it for months now and it’s night and day as far as clarity and emotional balance. Anxiety and stress diminish and my day is overall more energetic and better. It’s legit, people.

  •  

    Mary | VERIFIED PURCHASE

    I haven’t felt this good in years. I was 26 years when I was diagnosed with depression. Now I’m 65. I feel healthy, strong, my brain is clear, I don’t think my life is worthless

    Unlike competitors, we proudly prove our product is 99.9% pure, heavy metal-free, and USP grade. Click the image below to see our 3rd party lab test results

    Lab results

    Methylene Blue is a versatile salt renowned for its health-promoting benefits.


    
Initially used in 1891 to tackle malaria, this compound has stood the test of time, showcasing its reliability and efficacy.

    At low wellness servings, it can act as an alternative electron carrier in the mitochondria - supporting cellular energy processes that many people feel as clear, even-keeled mental energy

    “Is this… meth?”
    
 No. Methylene blue (methylthioninium chloride) is a century-old, FDA-recognized medicinal dye/redox molecule—not methamphetamine and not a stimulant drug.

    “Will it turn my brain blue?”


    No. The blue color is visible in the liquid itself and can tint soft tissues temporarily, but it doesn’t dye your brain. What people actually notice is clearer thinking—color stays in the glass, not your neurons.

    “Are my teeth going to stay blue?”


    Briefly, then no. A few minutes of tint on teeth/tongue is normal and rinses off.
Minimize it: use a straw, drop into water/juice, swish with plain water after, then brush as usual.

    “Will my pee be blue/green?”
 Sometimes, yes - totally expected and harmless. It’s just the compound (and its metabolites) exiting your body.

    “Is this the same as aquarium dye?”


    Absolutely not. TryAnnie uses USP/pharma-grade material only—never aquarium/industrial grades. Every batch is third-party tested (identity, purity, heavy metals) with a CoA available.

    “Is it safe? Any interactions?”


    Used appropriately and as labeled, methylene blue has a well-documented safety profile. That said:

    • Do not use with SSRIs/SNRIs/MAOIs or similar serotonergic meds (risk of serotonin toxicity).
    • Avoid if pregnant/breastfeeding.
    • G6PD deficiency: speak with your clinician first.
    • If you’re on prescription meds or have a condition, talk to your healthcare provider before use.

    “Will it keep me up at night?

    ”
 Some people feel more alert, so we suggest morning or early-afternoon use.


    “What about quality and contaminants?”

    • USP/pharma grade raw material
    • Heavy-metal screening and microbial testing
    • No propylene glycol, parabens, phthalates, artificial dyes, or mystery fillers
    • Bottled in quality-controlled (cGMP) facilities with batch traceability

    “Mess & stains - what to do?”

    • Use a straw or drop into a glass first, then add liquid.
    • Rinse mouth with water right after.
    • Spills on counters? Wipe quickly with soap and water; a little baking soda paste helps lift color.

    So much Methylene Blue online is industrial/aquarium grade and posted without third-party certificates.

    We use pharmaceutical/USP-grade only, and we publish batch COAs—because safety and purity come first.

    We are commited to provide highest quality Methylene Blue on the market.

    Our Hard no’s:

    • Use aquarium/industrial grades
    • Ship without third-party COA ( for identity, purity, heavy metals)
    • Add artificial dyes, flavors, propylene glycol, parabens, phthalates
    • Hide ingredients in “proprietary blends”

    1. Sharper Thinking & Focus

    Methylene blue supports brain cell energy, helping neurons fire more efficiently so you can think clearer and stay focused longer.


    2. Relief from Brain Fog

    
 By improving how your cells use oxygen, MB helps lift that sluggish haze and restores mental clarity.


    3. Steadier Energy Without Crashes
 Unlike caffeine or energy drinks, MB powers your mitochondria directly, giving you consistent energy without the jitters or comedown.


    4. Mood & Motivation Support
 Balanced energy flow in the brain helps reduce dips in mood and drive, keeping you more even-keeled and productive.


    5. Cellular Longevity & Protection


    MB helps reduce oxidative stress and supports mitochondrial health, promoting healthier aging and long-term resilience.


    6. Neuroprotective Benefits


    MB will protect neurons and support long-term brain and nerve health - important for memory and cognitive performance.

    Start low, go slow: begin 5–6 drops/day; increase if well-tolerated. (≈ 0.25 mg/drop.)

    Typical daily range: ~5–19 mg/day (≈ 20–30 drops).

    Timing: morning/early afternoon.
    Method: dilute in water/juice; straw helps; quick rinse after.

    Recommended cycling: e.g., 5 days on / 2 off.

    Safety: avoid with SSRIs/SNRIs/MAOIs medication; avoid during pregnancy/breastfeeding. Consult Your Clinicician first

    Discover Your Methylene Blue Solution

    Find out if methylene blue is right for you: from everyday brain fog and fatigue to longer-term issues like memory decline or recovery after illness. Select what fits you to learn more.

    This shows up as forgetting names, losing track of tasks, or struggling to stay concentrated. It’s often tied to stress, lack of sleep, or age-related decline in brain cell efficiency .Methylene Blue supports neuronal energy production, helping your brain process information faster and recall details more easily.

    Brain fog feels like mental haze, sluggish thinking, and slower processing — even when you’re rested. Triggers include stress, inflammation, toxins, or weak mitochondrial function. By improving how your cells use oxygen methylene blue helps lift the fog and restore clarity.

    Energy dips and emotional ups and downs often stem from stress, unstable neurotransmitters, or poor recovery. These swings can derail productivity and focus. Methylene blue balances cellular energy flow, supporting steadier mood and motivation.

    Memory decline and dementia are linked to aging, genetics, oxidative stress, and neuronal damage. These issues often begin gradually with forgetfulness and word-finding difficulty. Methylene blue crosses the blood-brain barrier and has been studied for its neuroprotective potential, helping to support long-term brain health.

    Chemotherapy often damages mitochondria, leading to lasting exhaustion, brain fog, and weakened energy production. Methylene blue supports mitochondrial repair and energy function, helping ease fatigue during recovery.

    When your cells can’t keep up, fatigue, slower healing, and signs of early aging appear. Oxidative stress and mitochondrial wear-and-tear drive these changes. Methylene blue helps reduce oxidative stress and improve mitochondrial resilience for healthier aging.

    Long hours and constant demands burn through mental energy fast. Methylene blue sustains focus and productivity without caffeine crashes.

    Brain fog feels like mental haze, sluggish thinking, and slower processing — even when you’re rested. Triggers include stress, inflammation, toxins, or weak mitochondrial function. By improving how your cells use oxygen methylene blue helps lift the fog and restore clarity.

    Juggling responsibilities leaves little energy left for you. Methylene blue provides clean energy and clarity to help you stay present and energized.

    High-stress environments demand quick thinking and reliable energy. Methylene blue fuels mitochondria to support sharp decision-making under pressure.

    Performance and recovery depend on strong mitochondrial output. Methylene blue enhances efficiency at the cellular level to boost endurance and recovery.

    Creative flow shuts down when the brain feels dull. Methylene blue supports clarity and faster connections so ideas come naturally.

    When energy, motivation, or focus haven’t bounced back after illness or chronic stress. Methylene Blue aids mitochondrial repair and helps restore sustained energy and mental resilience.

    They push your system harder without fixing why it’s tired. The result? Crashes, jitters, and worse sleep. → Methylene Blue works differently it restores the cell’s ability to make clean energy instead of forcing stimulation.

    Brain fog feels like mental haze, sluggish thinking, and slower processing — even when you’re rested. Triggers include stress, inflammation, toxins, or weak mitochondrial function. By improving how your cells use oxygen methylene blue helps lift the fog and restore clarity.

    Most nootropics mask symptoms or are a placebo without addressing root causes in the body. Methylene Blue works deeper by improving how your brain cells actually produce and use energy. Recovery & Wellness Protocols Helpful for stress and energy reset, but often only a momentum fix. Methylene Blue amplifies these benefits by improving oxygen use and energy metabolism in your cells.

    Helpful tools — but they’re only as effective as your mitochondria’s ability to respond. Methylene Blue amplifies these results by restoring energy flow at the cellular level, making recovery and resilience last longer.

    View full details

    • USP Grade

    • 99.9% Purity

    • 3rd Party Tested

    • Heavy Metal Free

    • USP Grade

    • 99.9% Purity

    • 3rd Party Tested

    • Heavy Metal Free

    • USP Grade

    • 99.9% Purity

    • 3rd Party Tested

    • Heavy Metal Free

    • USP Grade

    • 99.9% Purity

    • 3rd Party Tested

    • Heavy Metal Free

    • USP Grade

    • 99.9% Purity

    • 3rd Party Tested

    • Heavy Metal Free

    • USP Grade

    • 99.9% Purity

    • 3rd Party Tested

    • Heavy Metal Free

    • USP Grade

    • 99.9% Purity

    • 3rd Party Tested

    • Heavy Metal Free

    • USP Grade

    • 99.9% Purity

    • 3rd Party Tested

    • Heavy Metal Free

    • USP Grade

    • 99.9% Purity

    • 3rd Party Tested

    • Heavy Metal Free

    • USP Grade

    • 99.9% Purity

    • 3rd Party Tested

    • Heavy Metal Free

    Featured in Leading Publications for Its Clinically Proven Cognitive Benefits

    • “91% of users report improved mood and focus after consistent use for at least 2 weeks.”

       

    • “A scientific analysis confirming TryAnnie’s clinically proven cognitive and cellular benefits.”

       

    • “Methylene Blue Drops Are Revolutionizing Energy, Focus, and Cognitive Vitality in 2025.”

       

    • “TryAnnie’s Methylene Blue reviewed as the leading USP-grade pure liquid brand on the market.”

       

      Featured in Leading Publications for Its Clinically Proven Cognitive Benefits

      • “91% of users report improved mood and focus after consistent use for at least 2 weeks.”

         

      • “A scientific analysis confirming TryAnnie’s clinically proven cognitive and cellular benefits.”

         

      • “Methylene Blue Drops Are Revolutionizing Energy, Focus, and Cognitive Vitality in 2025.”

         

      • “TryAnnie’s Methylene Blue reviewed as the leading USP-grade pure liquid brand on the market.”

         

        Your Everyday Solution From One Proven Molecule

        Anti-Aging Effects

        Helps slow visible and cellular signs of aging by improving skin cell health, hydration, and repair.

         

        Research & Results

        • “In human skin cells and 3-D skin models, methylene blue reduced cell aging markers, improved hydration, and thickened skin layers within four weeks.”

           

        • “A 2021 scientific review found methylene blue supports mitochondria and reduces oxidative stress, showing potential to slow aging and neurodegeneration.”

           

          Neuroprotection & Long Term Brain Health

          Supports long-term brain health by protecting neurons and reducing harmful protein buildup linked to cognitive decline.

           

          Research & Results

          • “In Alzheimer’s research, people with active methylene blue levels showed slower memory decline and less brain shrinkage on scans..”

             

          • “Methylene blue reduced tau protein clumping in the brain, a main factor in Alzheimer’s progression.”

             

            Antimicrobial & Antiviral Defense

            Helps protect against bacteria and viruses by supporting the body’s natural defenses.

             

            Research & Results

            • “In lab experiments, methylene blue inactivated SARS-CoV-2 and influenza viruses and blocked their ability to enter human cells.”

               

            • “People taking methylene blue had lower depression and anxiety scores compared to those not taking it.”

               

              Sharper Focus & Clear Thinking

              Helps improve focus, thought processing, and decision-making by enhancing oxygen flow and brain energy.

               

              Research & Results

              • “In a placebo-controlled brain scan study, people taking methylene blue showed higher brain activity in regions linked to focus and attention.”

                 

              • “Participants given methylene blue demonstrated better sustained attention and task accuracy during performance tests compared to placebo.”

                 

                Memory Support & Mental Performance

                Improves both short-term and long-term memory by supporting brain oxygen use and healthy cell communication.

                 

                Research & Results Memory

                • After a single low dose, people made 7% more correct answers on a memory test one hour later compared to placebo.”

                   

                • “Brain scans showed stronger activity in memory circuits, confirming improved memory processing and recall.”

                   

                  Mood & Emotional Balance

                  Supports a real, lasting uplift in mood and helps maintain emotional stability through natural brain chemistry balance.

                   

                  Research & Results

                  • “People taking methylene blue had lower depression and anxiety scores compared to those not taking it.”

                     

                  • “People taking methylene blue had lower depression and anxiety scores compared to those not taking it.”

                     

                    Clean & Lasting Energy

                    Boosts natural energy production in the body by helping mitochondria make ATP — your cells’ main energy source.

                     

                    Research & Results

                    • “In studies with reduced brain blood flow, methylene blue preserved a key energy enzyme (cytochrome oxidase) and prevented memory decline linked to fatigue.”

                       

                    • “In cellular models, methylene blue helped keep energy production stable even under stress and aging conditions.”

                       

                      Antioxidant Support & Cell Protection

                      Protects brain and body cells from oxidative damage and helps fight free radicals that cause aging and inflammation.

                       

                      Research & Results

                      • “Research consistently describes methylene blue as neuroprotective, showing reduced oxidative damage and improved cell survival under stress.”

                         

                      • “Methylene blue reduced damaging molecules (superoxide) in mitochondria, protecting cells from oxidative stress.”

                         

                        How Methylene Blue WorksInside Your Body

                        Mechanism behind how a few drops can enhance your day

                        • Powers Your Brain with Clean & Lasting Energy
                          Methylene Blue supports the tiny power centers inside your cells so they can make energy more efficiently.

                          The result is a steady, natural lift in mental and physical energy that lasts throughout the day.

                        • Delivers Oxygen More Efficiently for Clearer Thinking
                          It helps your brain use oxygen more effectively, especially when you’re tired or under pressure.

                          Better oxygen use means sharper focus, quicker thinking, and less of that “fogged-over” feeling.

                        • Shields Your Brain Cells from Modern Stressors

                          Every day, your brain is hit by oxidative stress from poor sleep, screens, and fast living.Methylene Blue acts as a cell protector — helping your body handle stress and maintain balance.

                        • Supports Long-Term Brain Health and Healthy Aging

                          Over time, it helps keep your neurons healthy and functioning smoothly.That means stronger memory, sustained focus, and long-term cognitive resilience.

                          Don't take just our word for it.

                          Here's what the science says

                          CLINICAL STUDIES

                          Here are top findings of Independent, peer-reviewed trials that demonstrated following results:

                          74%

                          Of people with bipolar disorder improved on methylene blue in an early open-label series

                          98%

                          After only one low dose felt stronger activation in memory recall during complex tasks

                          99%

                          Reduction in viral infectivity observed in lab-based testing.

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                          User Reviews

                          We have collected over 35,000 everyday user experiences

                          95%

                          Said they could think faster, stay focused longer, and get through tasks more easily.

                          89%

                          Noticed they remembered things faster and made fewer small mistakes during the day.

                          85%

                          Said their mid-day crash disappeared, and they had steady energy and motivation all day.

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                          Join 50,000+ Fighting Back Against Brain Fog & Fatigue

                           4.85 Based On 50,000+ Satisfied Customers

                            Us vs Them

                            The #1 Risk With Methylene Blue? Hidden Heavy Metals. We’re the only brand that proves exactly what’s inside — safe, clean, lab-tested

                            START YOUR STORY NOW

                            verified 3rd Party Lab Tested For Safety

                            Us vs Them

                            The #1 Risk With Methylene Blue? Hidden Heavy Metals. We’re the only brand that proves exactly what’s inside — safe, clean, lab-testedstart you

                            START YOUR STORY NOW

                            verified 3rd Party Lab Tested For Safety

                            Frequentlyasked questions

                            Methylene Blue has been tested in human trials without any reported adverse effects. It is considered safe at therapeutic doses, which are less than 2 mg/kg—approximately 140 mg for a 70 kg individual.

                            Recent trials involving over 2800 participants have indicated that Methylene Blue can significantly enhance cognitive function and decrease brain atrophy. No adverse effects were reported in these studies.

                            Most methylene blue online is lab or aquarium grade, not meant for human use and can contain heavy metals or stabilizers.

                            Our formula is pharmaceutical-grade, 99.9% pure, and third-party tested to ensure no harmful contaminants.
                            Trace metal presence is lower than what’s found in a single serving of tuna per month.

                            Start with 3–5 drops in 4–8 oz of water, once or twice daily.

                            Morning use supports alertness; a smaller mid-day dose sustains clarity.

                            Avoid combining it immediately with vitamin C (it can neutralize MB).

                            Consistency is key - most users notice a difference within 3–7 days.

                            Some users feel cleaner energy and sharper focus within the first few uses.

                            As your cells recharge, improvements in clarity, motivation, and recall build gradually.

                            This isn’t a stimulant rush - it’s your mitochondria working better.

                            Yes, microdoses of methylene blue have been studied for supporting mitochondrial efficiency and brain resilience.
                            Our formulation is safe for long-term use and designed for daily wellness.
                            Always consult your healthcare provider if you’re on prescription medication or pregnant.

                            Users often describe:

                            • Smoother, steadier energy (no crashes or jitters)
                            • Easier word recall and sharper focus
                            • Calmer mood and better motivation
                              If it feels too strong, reduce your dose - less can often be more.

                            Methylene blue is not a drug or treatment, but studies suggest it may help support mitochondrial repair and energy recovery after cellular stress.

                            Many users include it in post-burnout or recovery protocols. Always consult your physician before use during treatment.

                            Totally normal - that’s how your body metabolizes MB.
                            To reduce visible tint, dilute in more water and rinse your mouth afterward.